Dorit Verhoeven, MD – PhD Student
Department of Pediatric Immunology, Rheumatology and Infectious diseases, Emma Children’s Hospital, Amsterdam UMC,
Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute.
The goal of my PhD project is to use this multidimensional approach to verify the role of signalling proteins and receptors of interest in B-cell-into-plasma-cell differentiation and translate this into clinically relevant therapeutic targets for patients with B cell mediated diseases. To study this, we investigate the cellular phenotype and function of lymphocytes in primary immunodeficiencies (PID), as human knock out models and through this delineate normal B cell function and differentiation in health and disease.
Verhoeven D., Stoppelenburg A.J., Meyer-Wentrup F., Boes M. (2018). Increased risk of hematologic malignancies in primary immunodeficiency disorders: opportunities for immunotherapy. Clinical Immunology, 190, 22-31