Prof. T.W. Kuijpers MD PhD

Pediatrician Consultant Infectious Diseases & Clinical Immunology, Amsterdam University Medical Center (AmsterdamUMC, Amsterdam, The Netherlands.

Principle Investigator T2B program. Work package leader WP 3, actively engaged with WP 6, WP 2/5 as well as WP 7

My research is largely translational of nature and reflects a longstanding collaboration between the Amsterdam University Medical Center (AUMC) and Sanquin  as part of the University of Amsterdam (UvA). Disease manifestations of severe invasive/systemic infections or hyperinflammation with organ failure are the focus of my research, encompassing B cells, T cells and the life cycle of neutrophils, including their development and function. Investigations in genetically characterized patients have increased our understanding of disease. Insight from such ‘experiments of nature’ has helped to also improve clinical outcome by immunomodulation or immunosuppressive drugs in a more rational, predictive fashion in clinical autoimmune diseases, autoinflammation and severe tissue injury.

Recent publications

  1. Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E, Maimaris J, Penkett CJ, Stephens J, Deevi SVV, Sanchis-Juan A, Gleadall NS, Thomas MJ, Sargur RB, Gordins P, Baxendale HE, Brown M, Tuijnenburg P, Worth A, Hanson S, Linger RJ, Buckland MS, Rayner-Matthews PJ, Gilmour KC, Samarghitean C, Seneviratne SL, Sansom DM, Lynch AG, Megy K, Ellinghaus E, Ellinghaus D, Jorgensen SF, Karlsen TH, Stirrups KE, Cutler AJ, Kumararatne DS, Chandra A, Edgar JDM, Herwadkar A, Cooper N, Grigoriadou S, Huissoon AP, Goddard S, Jolles S, Schuetz C, Boschann F; Primary Immunodeficiency Consortium for the NIHR Bioresource, Lyons PA, Hurles ME, Savic S, Burns SO, Kuijpers TW*, Turro E*, Ouwehand WH*, Thrasher AJ*, Smith KGC. (equal contribution). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. 2020 May 6. doi: 10.1038/s41586-020-2265-1. Epub ahead of print.
  2. Sprenkeler EGG, Henriet SSV, Tool ATJ, Kreft IC, van der Bijl I, Aarts CEM, van Houdt M, Verkuijlen PJJH, van Aerde K, Jaspers G, van Heijst A, Koole W, Gardeitchik T, Geissler J, de Boer M, Tol S, Bruggeman CW, van Alphen FPJ, Verhagen HJMP, van den Akker E, Janssen H, van Bruggen R, van den Berg TK, Liem KD, Kuijpers TW. MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization. Blood. 2020 Jun 11;135(24):2171-2181.
  3. Volpi S, Cicalese MP, Tuijnenburg P, Tool ATJ, Cuadrado E, Abu-Halaweh M, Ahanchian H, Alzyoud R, Akdemir ZC, Barzaghi F, Blank A, Boisson B, Bottino C, Brigida I, Caorsi R, Casanova JL, Chiesa S, Chinn IK, Dückers G, Enders A, Erichsen HC, Forbes LR, Gambin T, Gattorno M, Karimiani EG, Giliani S, Gold MS, Jacobsen EM, Jansen MH, King JR, Laxer RM, Lupski JR, Mace E, Marcenaro S, Maroofian R, Meijer AB, Niehues T, Notarangelo LD, Orange J, Pannicke U, Pearson C, Picco P, Quinn PJ, Schulz A, Seeborg F, Stray-Pedersen A, Tawamie H, van Leeuwen EMM, Aiuti A, Yeung R, Schwarz K, Kuijpers TW. A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency. J Allergy Clin Immunol. 2019 Feb 13. pii: S0091-6749(19)30206-4.
  4. Nagelkerke SQ, Schmidt DE, de Haas M, Kuijpers TW. Genetic Variation in Low-To-Medium-Affinity Fcγ Receptors: Functional Consequences, Disease Associations, and Opportunities for Personalized Medicine. Front Immunol. 2019;10:2237.
  5. Tuijnenburg P, Lango Allen H, Burns SO, Greene D, Jansen MH, Staples E, Stephens J, Carss KJ, Biasci D, Baxendale H, Thomas M, Chandra A, Kiani-Alikhan S, Longhurst HJ, Seneviratne SL, Oksenhendler E, Simeoni I, de Bree GJ, Tool ATJ, van Leeuwen EMM, Ebberink EHTM, Meijer AB, Tuna S, Whitehorn D, Brown M, Turro E, Thrasher AJ, Smith KGC, Thaventhiran JE, Kuijpers TW; NIHR BioResource–Rare Diseases Consortium. Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans. J Allergy Clin Immunol. 2018 Mar 2. pii: S0091-6749(18)30286-0

Currently supervising PhD research of

  • Dorit Verhoeven
  • Karolien Kielbassa
  • Linda van der Weele
  • Unrelated to T2B: 8 additional PhD students