WP 6: Fab glycosylation: structure, function and relevance in autoimmunity and oncology
In work package 6, we specifically zoom in into Fab glycosylation of antibodies and the B cells that produce these antibodies. There is accumulating evidence that Fab glycans, which are introduced during somatic hypermutation, are highly relevant to pathogenic B cells in both autoimmunity and cancer. However, at present, the underlying selective mechanisms in lymphoma and autoimmunity, their commonalities and differences, remain unknown. Moreover, little is known on the role of Fab-glycans in physiological humoral immune responses.